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KMID : 1007320080140030221
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Journal of the Korean Society of Menopause
2008 Volume.14 No. 3 p.221 ~ p.226
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Is There Any Difference in Serum Estradiol Level between Morning and Evening Oral Estrogen Administration in Postmenopausal Women?
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Beak Su-Jin
Kang Byung-Moon
Kim Ji-Sun
Koo Yun-Hee
Kim Sung-Hoon
Chae Hee-Dong
Kim Chung-Hoon
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Abstract
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Objectives: To evaluate the serum estradiol (E2) level after hormone therapy (HT) at different times of the day (8 a.m. and 8 p.m.) in Korean postmenopausal women.
Methods: A prospective randomized clinical trial was conducted on 51 postmenopausal women without contraindications to HT from January 2004 to December 2005. Patients were divided into two treatment groups and treated with pill containing estradiol valerate 2 mg and norethindrone 5 mg. Patients in the morning group (Group A, n=23) received the pill at 8 a.m. and patients in the evening group (Group B, n=22) received the pill at 8 p.m. for 3 months.
Results: Groups were homogenous for age and basal parameters. Serum E2 levels increased significantly (P＜0.05) after 3 months HT in both groups. However, there was no difference in the baseline level of serum E2. In addition, there were no differences in the serum E2 level after 3 months HT between the 2 groups (Group A, 221.2±80.8 pg/ml; and Group B, 217.5±103.3 pg/ml; P=0.8).
Conclusion: Morning or evening administration of oral HT did not show any difference in the serum E2 levels after 3 months HT.
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KEYWORD
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Hormone therapy, Estradiol level, Postmenopausal women
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